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هیستون استیل ترانسفراز
The extent of histone acetylation is determined by the relative activities of two host cell enzymes, histone acetyltransferase, which adds acetyl groups to lysines on histone proteins, and histone deacetylase, which removes acetyl groups from the histone.
Increased histone acetylation, which leads to increased gene transcription, can be accomplished either by increasing the expression of histone acetyltransferase or by decreasing the activity of histone deacetylase.
One effective strategy to do this is to target histone acetyltransferase specifically to the site of target gene insertion to ensure that the target gene is actively and continuously transcribed.
Histone acetylation is catalyzed by the enzyme histone acetyltransferase (HAT).
The LexA pro tein specifically binds to the LexA recognition site upstream of the gene encoding GFP and brings with it the fused histone acetyltransferase pro tein that acetylates histones associated with the promoter region and pro motes a higher level of GFP transcription.
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